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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tgm2
Name: transglutaminase 2
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgm2increases activityEXP 6480464CTDEthanol results in increased activity of TGM2 proteinPMID:10801782
Tgm2increases expressionEXP 6480464CTDEthanol results in increased expression of TGM2 mRNAPMID:10801782
Tgm2multiple interactionsEXP 6480464CTDEthanol inhibits the reaction [Phenylephrine results in decreased activity of TGM2 protein]; Putrescine inhibits the reaction [Ethanol results in increased activity of TGM2 protein]PMID:10801782
Tgm2increases activityISOTGM2 (Homo sapiens)6480464CTDEthanol results in increased activity of TGM2 proteinPMID:18295389
Tgm2increases activityISOTgm2 (Mus musculus)6480464CTDEthanol results in increased activity of TGM2 proteinPMID:11696672
Tgm2increases expressionISOTGM2 (Homo sapiens)6480464CTDEthanol results in increased expression of TGM2 mRNAPMID:18295389
Tgm2increases expressionISOTgm2 (Mus musculus)6480464CTDEthanol results in increased expression of TGM2 mRNAPMID:11696672 PMID:30319688
Tgm2multiple interactionsISOTGM2 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Ethanol results in increased activity of TGM2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ethanol results in increased activity of TGM2 protein]; [[Gasoline co-treated with Ethanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of TGM2 mRNA; Ethanol promotes the reaction [RELA protein binds to TGM2 promoter]; pinocembrin inhibits the reaction [Ethanol results in increased activity of TGM2 protein]; pinocembrin inhibits the reaction [Ethanol results in increased expression of TGM2 mRNA]; Propolis inhibits the reaction [Ethanol results in increased activity of TGM2 protein]; Propolis inhibits the reaction [Ethanol results in increased expression of TGM2 mRNA]; Tosyllysine Chloromethyl Ketone inhibits the reaction [Ethanol results in increased activity of TGM2 protein]; Tosyllysine Chloromethyl Ketone inhibits the reaction [Ethanol results in increased expression of TGM2 mRNA]PMID:18295389 PMID:29432896
Tgm2multiple interactionsISOTgm2 (Mus musculus)6480464CTD[Carbon Tetrachloride co-treated with Ethanol] results in increased expression of TGM2 mRNAPMID:30517762
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