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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619979
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hdac4
Name: histone deacetylase 4
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hdac4increases expressionEXP 6480464CTDEthanol results in increased expression of HDAC4 proteinPMID:23544086
Hdac4multiple interactionsEXP 6480464CTDEthanol promotes the reaction [HDAC3 protein binds to HDAC4 protein binds to HDAC5 protein binds to HDAC7 protein]; ursodoxicoltaurine inhibits the reaction [Ethanol promotes the reaction [HDAC3 protein binds to HDAC4 protein binds to HDAC5 protein binds to HDAC7 protein]]; ursodoxicoltaurine inhibits the reaction [Ethanol results in increased expression of HDAC4 protein]PMID:23544086
Hdac4increases expressionISOHdac4 (Mus musculus)6480464CTDEthanol results in increased expression of HDAC4 mRNAPMID:30319688 PMID:35639301
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