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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3752
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Spp1
Name: secreted phosphoprotein 1
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Spp1decreases expressionEXP 6480464CTDEthanol results in decreased expression of SPP1 mRNAPMID:31887396
Spp1increases expressionEXP 6480464CTDEthanol results in increased expression of SPP1 mRNA; Ethanol results in increased expression of SPP1 proteinPMID:18703563 PMID:33645892
Spp1multiple interactionsEXP 6480464CTDEnalapril inhibits the reaction [Ethanol results in decreased expression of SPP1 mRNA]; Ethanol promotes the reaction [Tramadol results in increased expression of SPP1 protein]; lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [Ethanol results in increased expression of SPP1 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of SPP1 protein]PMID:18703563 PMID:31887396 PMID:33645892
Spp1decreases expressionISOSPP1 (Homo sapiens)6480464CTDEthanol results in decreased expression of SPP1 mRNAPMID:31059573
Spp1increases expressionISOSpp1 (Mus musculus)6480464CTDEthanol results in increased expression of SPP1 mRNA; Ethanol results in increased expression of SPP1 proteinPMID:18703563
Spp1increases expressionISOSPP1 (Homo sapiens)6480464CTDEthanol results in increased expression of SPP1 proteinPMID:18703563
Spp1multiple interactionsISOSpp1 (Mus musculus)6480464CTD[Carbon Tetrachloride co-treated with Ethanol] results in increased expression of SPP1 mRNA; lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [Ethanol results in increased expression of SPP1 protein]; SPP1 protein affects the reaction [[Ethanol co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in decreased expression of PPARA mRNA]PMID:18703563 PMID:30517762
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