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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3732
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod2
Name: superoxide dismutase 2
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod2increases expressionEXP 6480464CTDEthanol results in increased expression of SOD2 mRNA; Ethanol results in increased expression of SOD2 proteinPMID:10787391 PMID:24769256
Sod2multiple interactionsEXP 6480464CTDsalvianolic acid B inhibits the reaction [Ethanol results in increased expression of SOD2 protein]; Vitamin E affects the reaction [Ethanol affects the activity of SOD2 protein]PMID:10787391 PMID:24769256
Sod2decreases activityISOSod2 (Mus musculus)6480464CTDEthanol results in decreased activity of SOD2 proteinPMID:20016022
Sod2decreases expressionISOSod2 (Mus musculus)6480464CTDEthanol results in decreased expression of SOD2 mRNA; Ethanol results in decreased expression of SOD2 proteinPMID:24065054 PMID:24144995
Sod2increases activityISOSod2 (Mus musculus)6480464CTDEthanol results in increased activity of SOD2 proteinPMID:19063909 PMID:20016022
Sod2increases expressionISOSod2 (Mus musculus)6480464CTDEthanol results in increased expression of SOD2 mRNA; Ethanol results in increased expression of SOD2 proteinPMID:19951287 PMID:24095927 PMID:25460735
Sod2multiple interactionsISOSod2 (Mus musculus)6480464CTDDeferoxamine inhibits the reaction [SOD2 protein affects the reaction [Ethanol results in increased abundance of Iron]]; NR1H4 gene mutant form inhibits the reaction [Ethanol results in increased expression of SOD2 mRNA]; SOD2 protein affects the reaction [Ethanol results in decreased expression of TFAM protein]; SOD2 protein affects the reaction [Ethanol results in increased abundance of Iron]; SOD2 protein affects the reaction [Ethanol results in increased expression of NOS2 protein]; SOD2 protein inhibits the reaction [Ethanol results in increased expression of NOS2 protein]PMID:19063909 PMID:20016022 PMID:25460735
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