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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731046 Species: Homo sapiens RGD Object: Gene Symbol: CCL2 Name: chemokine (C-C motif) ligand 2

Acc ID: CHEBI:16118 Term: berberine Definition: A berberine alkaloid that has formula C20H18NO4. CasRN: 2086-83-1 Chemical ID: MESH:D001599

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	Berberine inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein] Berberine inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA] Berberine inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA] Berberine inhibits the reaction [TNF protein results in increased secretion of CCL2 protein]	PMID:16391493