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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2326
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cebpa
Name: CCAAT/enhancer binding protein alpha
Acc ID: CHEBI:16118
Term: berberine
Definition: A botanical anti-fungal agent that has formula C20H18NO4.
Chemical ID: MESH:D001599
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cebpadecreases expressionISOCebpa (Mus musculus)6480464CTDBerberine results in decreased expression of CEBPA mRNA; Berberine results in decreased expression of CEBPA proteinPMID:37511356
Cebpadecreases expressionISOCEBPA (Homo sapiens)6480464CTDBerberine results in decreased expression of CEBPA mRNAPMID:26478571
Cebpamultiple interactionsISOCebpa (Mus musculus)6480464CTDBerberine inhibits the reaction [Clozapine results in increased expression of CEBPA mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA protein]; Berberine inhibits the reaction [Risperidone results in increased expression of CEBPA mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of CEBPA protein]PMID:20564506
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