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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1566119
Species: Rattus norvegicus
RGD Object: Gene
Symbol: H2ax
Name: H2A.X variant histone
Acc ID: CHEBI:16118
Term: berberine
Definition: A botanical anti-fungal agent that has formula C20H18NO4.
Chemical ID: MESH:D001599
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
H2axdecreases expressionISOH2AX (Homo sapiens)6480464CTDBerberine results in decreased expression of H2AX mRNA; Berberine results in decreased expression of H2AX proteinPMID:23363784 PMID:27311644
H2axincreases expressionISOH2AX (Homo sapiens)6480464CTDBerberine results in increased expression of H2AX protein modified formPMID:23747414
H2axmultiple interactionsISOH2AX (Homo sapiens)6480464CTDTOP2A protein affects the reaction [Berberine results in increased expression of H2AX protein modified form]PMID:23747414
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