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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3952 Species: Rattus norvegicus RGD Object: Gene Symbol: Vcam1 Name: vascular cell adhesion molecule 1

Acc ID: CHEBI:16113 Term: cholesterol Definition: A cholestanoid consisting of cholestane having a double bond at the 5,6-position as well as a 3beta-hydroxy group. CasRN: 57-88-5 Chemical ID: MESH:D002784

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:11481	6480464	CTD	Cholesterol results in increased expression of VCAM1 mRNA Cholesterol results in increased expression of VCAM1 protein	PMID:19028402
multiple interactions	ISO	RGD:11481	6480464	CTD	Cholesterol inhibits the reaction [irbesartan results in increased expression of VCAM1 mRNA] Cholesterol inhibits the reaction [irbesartan results in increased expression of VCAM1 protein]	PMID:19028402