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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1323187
Species: Mus musculus
RGD Object: Gene
Symbol: Dapk1
Name: death associated protein kinase 1
Acc ID: CHEBI:16113
Term: cholesterol
Definition: A cholestanoid consisting of cholestane having a double bond at the 5,6-position as well as a 3beta-hydroxy group.
Chemical ID: MESH:D002784
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dapk1increases expressionISODapk1 (Rattus norvegicus)6480464CTDCholesterol analog results in increased expression of DAPK1 mRNAPMID:19477266
Dapk1multiple interactionsISODapk1 (Rattus norvegicus)6480464CTD6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Cholesterol analog results in increased expression of DAPK1 mRNA]; Acetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of DAPK1 mRNA]PMID:19477266
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