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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3317
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pgr
Name: progesterone receptor
Acc ID: CHEBI:15930
Term: atrazine
Definition: A diamino-1,3,5-triazine that is 1,3,5-triazine-2,4-diamine substituted by a chloro group at position 6 while one of hydrogens of each amino group is replaced respectively by an ethyl and a propan-2-yl group.
Chemical ID: MESH:D001280
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pgraffects methylationEXP 6480464CTDAtrazine affects the methylation of PGR genePMID:35440735
Pgrmultiple interactionsEXP 6480464CTD[Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]] inhibits the reaction [CGA protein results in increased expression of PGR mRNA]; Atrazine inhibits the reaction [Progesterone binds to PGR protein]; U 0126 inhibits the reaction [[Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]] inhibits the reaction [CGA protein results in increased expression of PGR mRNA]]PMID:23583632 PMID:8812239
Pgrmultiple interactionsISOPGR (Homo sapiens)6480464CTDAtrazine inhibits the reaction [Chorionic Gonadotropin results in increased expression of PGR mRNA]PMID:26923738
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