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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2074
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ahr
Name: aryl hydrocarbon receptor
Acc ID: CHEBI:15930
Term: atrazine
Definition: A diamino-1,3,5-triazine that is 1,3,5-triazine-2,4-diamine substituted by a chloro group at position 6 while one of hydrogens of each amino group is replaced respectively by an ethyl and a propan-2-yl group.
Chemical ID: MESH:D001280
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ahrdecreases expressionEXP 6480464CTDAtrazine results in decreased expression of AHR mRNAPMID:36841081
Ahrdecreases expressionISOAHR (Homo sapiens)6480464CTDAtrazine results in decreased expression of AHR mRNAPMID:22378314
Ahrincreases expressionISOAhr (Mus musculus)6480464CTDAtrazine results in increased expression of AHR proteinPMID:36216167
Ahrmultiple interactionsISOAhr (Mus musculus)6480464CTD[Lycopene co-treated with Atrazine] results in increased expression of AHR mRNA; Lycopene inhibits the reaction [Atrazine results in increased expression of AHR protein]PMID:36216167
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