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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619991 Species: Rattus norvegicus RGD Object: Gene Symbol: Vegfa Name: vascular endothelial growth factor A

Acc ID: CHEBI:15864 Term: luteolin Definition: A 3'-hydroxyflavonoid which is thought to play an important role in the human body as an antioxidant, a free radical scavenger, an agent in the prevention of inflammation, a promoter of carbohydrate metabolism, and an immune system modulator. CasRN: 491-70-3 Chemical ID: MESH:D047311

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:731072	6480464	CTD	Luteolin results in decreased expression of VEGFA protein Luteolin results in decreased expression of VEGFA mRNA	PMID:19005980