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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3889 Species: Rattus norvegicus RGD Object: Gene Symbol: Tp53 Name: tumor protein p53

Acc ID: CHEBI:15846 Term: NAD(+) Definition: The oxidised form of nicotinamide adenine dinucleotide found in all living cells. In metabolism, NAD(+) is involved in redox reactions, carrying electrons from one reaction to another. CasRN: 53-84-9 Chemical ID: MESH:D009243

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:70502	6480464	CTD	[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of TP53 gene bathocuproine inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of TP53 gene] CAT protein inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of TP53 gene]	PMID:10334203
decreases expression	ISO	RGD:70502	6480464	CTD	NAD results in decreased expression of TP53 protein	PMID:12390773
multiple interactions	ISO	RGD:11440	6480464	CTD	NAD promotes the reaction [Acetaminophen results in decreased expression of TRP53 protein]	PMID:11461765