• View As List
• View As Table

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2765 Species: Rattus norvegicus RGD Object: Gene Symbol: Gstt1 Name: glutathione S-transferase theta 1

Acc ID: CHEBI:15767 Term: dichloromethane Definition: A member of the class of chloromethanes that is methane in which two of the hydrogens have been replaced by chlorine. A dense, non-flammible colourless liquid at room temperature (b.p. 40degreeC, d = 1.33) which is immiscible with water, it is widely used as a solvent, a paint stripper, and for the removal of caffeine from coffee and tea. CasRN: 75-09-2 Chemical ID: MESH:D008752

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects metabolic processing	ISO	RGD:736934	6480464	CTD	GSTT1 gene polymorphism affects the metabolism of Methylene Chloride	PMID:7979958
increases metabolic processing	ISO	RGD:736934	6480464	CTD	GSTT1 protein results in increased metabolism of Methylene Chloride	PMID:12054768 PMID:11446825
multiple interactions	ISO	RGD:10700	6480464	CTD	GSTT1 protein affects the metabolism of and results in increased activity of Methylene Chloride	PMID:15683365 PMID:8761485
affects metabolic processing	ISO	RGD:736934	6480464	CTD	GSTT1 protein affects the metabolism of Methylene Chloride	PMID:15683365 PMID:14727918
affects metabolic processing	ISO	RGD:10700	6480464	CTD	GSTT1 protein affects the metabolism of Methylene Chloride	PMID:9854036 PMID:17827337 PMID:8670055
multiple interactions	ISO	RGD:10700	6480464	CTD	[GSTT1 protein affects the metabolism of Methylene Chloride] which results in increased abundance of Formaldehyde	PMID:16765633
affects metabolic processing	EXP		6480464	CTD	GSTT1 protein affects the metabolism of Methylene Chloride	PMID:8670055 PMID:1848757
affects metabolic processing	EXP		6480464	CTD	GSTT1 protein affects the metabolism of Methylene Chloride	PMID:14727918
multiple interactions	EXP		6480464	CTD	GSTT1 protein results in increased metabolism of and results in increased activity of Methylene Chloride	PMID:10413528
increases metabolic processing	EXP		6480464	CTD	GSTT1 protein results in increased metabolism of Methylene Chloride	PMID:11453994
increases metabolic processing	ISO	RGD:736934	6480464	CTD	GSTT1 protein results in increased metabolism of Methylene Chloride	PMID:11446825 PMID:12054768
affects metabolic processing	ISO	RGD:10700	6480464	CTD	GSTT1 protein affects the metabolism of Methylene Chloride	PMID:17827337 PMID:9854036 PMID:8670055
multiple interactions	ISO	RGD:10700	6480464	CTD	GSTT1 protein affects the metabolism of and results in increased activity of Methylene Chloride	PMID:8761485 PMID:15683365
affects metabolic processing	EXP		6480464	CTD	GSTT1 protein affects the metabolism of Methylene Chloride	PMID:1848757 PMID:8670055
affects metabolic processing	ISO	RGD:736934	6480464	CTD	GSTT1 protein affects the metabolism of Methylene Chloride	PMID:14727918 PMID:15683365
affects metabolic processing	ISO	RGD:10700	6480464	CTD	GSTT1 protein affects the metabolism of Methylene Chloride	PMID:17827337 PMID:8670055 PMID:9854036
affects metabolic processing	ISO	RGD:10700	6480464	CTD	GSTT1 protein affects the metabolism of Methylene Chloride	PMID:8670055 PMID:9854036 PMID:17827337
affects response to substance	ISO	RGD:736934	6480464	CTD	GSTT1 protein alternative form affects the susceptibility to Methylene Chloride	PMID:20837120