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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2475
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
Acc ID: CHEBI:15767
Term: dichloromethane
Definition: A member of the class of chloromethanes that is methane in which two of the hydrogens have been replaced by chlorine. A dense, non-flammible colourless liquid at room temperature (b.p. 40degreeC, d = 1.33) which is immiscible with water, it is widely used as a solvent, a paint stripper, and for the removal of caffeine from coffee and tea.
Chemical ID: MESH:D008752
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2e1increases metabolic processingEXP 6480464CTDCYP2E1 protein results in increased metabolism of Methylene ChloridePMID:8889796
Cyp2e1multiple interactionsEXP 6480464CTD3-xylene promotes the reaction [CYP2E1 protein results in increased metabolism of Methylene Chloride]; Benzene promotes the reaction [CYP2E1 protein results in increased metabolism of Methylene Chloride]; Toluene promotes the reaction [CYP2E1 protein results in increased metabolism of Methylene Chloride]PMID:8889796
Cyp2e1increases oxidationISOCYP2E1 (Homo sapiens)6480464CTDCYP2E1 protein results in increased oxidation of Methylene ChloridePMID:1664256
Cyp2e1multiple interactionsISOCyp2e1 (Mus musculus)6480464CTD[[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which results in increased expression of CYP2E1 mRNAPMID:29335169
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