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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2200 Species: Rattus norvegicus RGD Object: Gene Symbol: Bcl2l1 Name: Bcl2-like 1

Acc ID: CHEBI:15738 Term: staurosporine Definition: An indolocarbazole alkaloid that has formula C28H26N4O3. CasRN: 62996-74-1 Chemical ID: MESH:D019311

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects expression	EXP		6480464	CTD	Staurosporine affects the expression of BCL2L1 mRNA	PMID:11296547
decreases response to substance	ISO	RGD:735516	6480464	CTD	BCL2L1 protein results in decreased susceptibility to Staurosporine	PMID:11468182
decreases response to substance	ISO	RGD:1552009	6480464	CTD	BCL2L1 protein results in decreased susceptibility to Staurosporine	PMID:10679475
decreases response to substance	EXP		6480464	CTD	BCL2L1 gene mutant form results in decreased susceptibility to Staurosporine	PMID:10970895
increases expression	ISO	RGD:735516	6480464	CTD	Staurosporine results in increased expression of BCL2L1 protein alternative form	PMID:21256112