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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69127 Species: Mus musculus RGD Object: Gene Symbol: Ccl5 Name: chemokine (C-C motif) ligand 5

Acc ID: CHEBI:15551 Term: prostaglandin E2 Definition: Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins. CasRN: 363-24-6 Chemical ID: MESH:D015232

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:1604061	6480464	CTD	Dinoprostone results in decreased expression of CCL5 mRNA	PMID:16303787
multiple interactions	EXP		6480464	CTD	Dinoprostone inhibits the reaction [Reactive Oxygen Species results in increased expression of CCL5 mRNA] Dinoprostone inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]	PMID:10495789
multiple interactions	EXP		6480464	CTD	Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL5 mRNA] Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL5 protein]	PMID:17667525