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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3435
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptger3
Name: prostaglandin E receptor 3
Acc ID: CHEBI:15551
Term: prostaglandin E2
Definition: Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.
Chemical ID: MESH:D015232
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptger3affects bindingEXP 6480464CTDDinoprostone binds to PTGER3 protein; Dinoprostone binds to PTGER3 protein alternative formPMID:15937517
Ptger3increases expressionEXP 6480464CTDDinoprostone results in increased expression of PTGER3 mRNAPMID:14636300
Ptger3multiple interactionsEXP 6480464CTDPTGER3 mutant form inhibits the reaction [Dinoprostone results in increased expression of PPP1R9B protein]; PTGER3 protein affects the reaction [Dinoprostone results in decreased transport of Calcium]PMID:12535167 PMID:17408863
Ptger3affects response to substanceISOPtger3 (Mus musculus)6480464CTDPTGER3 affects the susceptibility to DinoprostonePMID:11375261
Ptger3increases activityISOPtger3 (Mus musculus)6480464CTDDinoprostone results in increased activity of PTGER3 proteinPMID:10357836
Ptger3multiple interactionsISOPTGER3 (Homo sapiens)6480464CTDDinoprostone binds to and results in increased activity of PTGER3 protein; Endocannabinoids inhibits the reaction [Dinoprostone binds to and results in increased activity of PTGER3 protein]PMID:30102254
Ptger3multiple interactionsISOPtger3 (Mus musculus)6480464CTD[Dinoprostone results in increased activity of PTGER3 protein] which results in decreased abundance of Cyclic AMP; Dinoprostone binds to and results in increased activity of PTGER3 proteinPMID:10357836 PMID:17242161
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