• View As List
• View As Table

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10439 Species: Mus musculus RGD Object: Gene Symbol: Cyp1b1 Name: cytochrome P450, family 1, subfamily b, polypeptide 1

Acc ID: CHEBI:15551 Term: prostaglandin E2 Definition: Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins. CasRN: 363-24-6 Chemical ID: MESH:D015232

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:736765	6480464	CTD	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 mRNA] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 protein] 6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 mRNA] 6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 protein] AH 23848 inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 mRNA] AH 23848 inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 protein] fulvestrant inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 mRNA] fulvestrant inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 protein] N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 mRNA] N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 protein] N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 mRNA] N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 protein] PD 98059 inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 mRNA] PD 98059 inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 protein]	PMID:20093341
increases expression	ISO	RGD:736765	6480464	CTD	Dinoprostone results in increased expression of CYP1B1 mRNA Dinoprostone results in increased expression of CYP1B1 protein	PMID:20093341