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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735204 Species: Rattus norvegicus RGD Object: Gene Symbol: Panx1 Name: Pannexin 1

Acc ID: CHEBI:15422 Term: ATP Definition: A purine ribonucleoside 5'-triphosphate that has formula C10H16N5O13P3. CasRN: 56-65-5 Chemical ID: MESH:D000255

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases activity	ISO	RGD:1347653	6480464	CTD	Adenosine Triphosphate results in decreased activity of PANX1 protein	PMID:19023039
increases export	ISO	RGD:1347653	6480464	CTD	PANX1 protein results in increased export of Adenosine Triphosphate	PMID:19213873
multiple interactions	ISO	RGD:1347653	6480464	CTD	Probenecid inhibits the reaction [PANX1 protein results in increased export of Adenosine Triphosphate] Carbenoxolone inhibits the reaction [PANX1 protein results in increased export of Adenosine Triphosphate]	PMID:19213873
decreases activity	ISO	RGD:1552235	6480464	CTD	Adenosine Triphosphate results in decreased activity of PANX1 protein	PMID:19023039