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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3241 Species: Rattus norvegicus RGD Object: Gene Symbol: P2rx7 Name: purinergic receptor P2X, ligand-gated ion channel, 7

Acc ID: CHEBI:15422 Term: ATP Definition: A purine ribonucleoside 5'-triphosphate that has formula C10H16N5O13P3. CasRN: 56-65-5 Chemical ID: MESH:D000255

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:730814	6480464	CTD	P2RX7 protein affects the reaction [Adenosine Triphosphate results in increased transport of Barium] P2RX7 protein affects the reaction [Adenosine Triphosphate results in increased secretion of SELL protein]	PMID:11003599
decreases response to substance	ISO	RGD:730815	6480464	CTD	P2RX7 gene mutant form results in decreased susceptibility to Adenosine Triphosphate	PMID:17728465
increases activity	ISO	RGD:730814	6480464	CTD	Adenosine Triphosphate results in increased activity of P2RX7 protein	PMID:19023039
increases activity	EXP		6480464	CTD	Adenosine Triphosphate results in increased activity of P2RX7 protein	PMID:19023039
increases activity	ISO	RGD:730815	6480464	CTD	Adenosine Triphosphate results in increased activity of P2RX7 protein	PMID:19023039
increases activity	ISO	RGD:730815	6480464	CTD	Adenosine Triphosphate results in increased activity of P2RX7 protein	PMID:19023039 PMID:21638035
multiple interactions	ISO	RGD:730815	6480464	CTD	3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX7 protein] coomassie Brilliant Blue inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX7 protein] pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX7 protein]	PMID:21638035