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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3112
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc1
Name: ATP binding cassette subfamily C member 1
Acc ID: CHEBI:15422
Term: ATP
Definition: An adenosine 5'-phosphate in which the 5'-phosphate is a triphosphate group. It is involved in the transportation of chemical energy during metabolic pathways.
Chemical ID: MESH:D000255
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc1affects activityISOABCC1 (Homo sapiens)6480464CTDAdenosine Triphosphate affects the activity of ABCC1 proteinPMID:32472168
Abcc1affects bindingISOABCC1 (Homo sapiens)6480464CTDAdenosine Triphosphate binds to ABCC1 proteinPMID:15355964 PMID:15737336
Abcc1increases hydrolysisISOAbcc1 (Mus musculus)6480464CTDABCC1 protein results in increased hydrolysis of Adenosine TriphosphatePMID:10856430
Abcc1increases hydrolysisISOABCC1 (Homo sapiens)6480464CTDABCC1 protein results in increased hydrolysis of Adenosine TriphosphatePMID:16156793 PMID:18955043
Abcc1multiple interactionsISOAbcc1 (Mus musculus)6480464CTDDaunorubicin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; Vanadates inhibits the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]PMID:10856430
Abcc1multiple interactionsISOABCC1 (Homo sapiens)6480464CTD[Adenosine Triphosphate affects the activity of ABCC1 protein] which results in increased transport of Acetaminophen metabolite; ABCC1 protein binds to and results in increased degradation of Adenosine Triphosphate; ABCC1 protein binds to and results in increased hydrolysis of Adenosine Triphosphate; ABCC1 protein mutant form binds to and results in increased hydrolysis of Adenosine Triphosphate; Adenosine Triphosphate binds to and affects the folding of ABCC1 protein; Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of Bilirubin]; Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of estradiol-17 beta-glucuronide]; Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of Leukotriene C4]; daidzein promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; Disulfiram affects the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; hesperetin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; naringenin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; nobiletin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; Quercetin affects the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; Resveratrol promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; Silymarin inhibits the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]PMID:11278000 PMID:14978246 PMID:15245331 PMID:15355964 PMID:15459206 PMID:15838832 PMID:16156793 PMID:18336795 PMID:18955043 PMID:32472168
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