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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621157
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Txn1
Name: thioredoxin 1
Acc ID: CHEBI:15421
Term: perillyl aldehyde
Definition: An aldehyde that is cyclohex-1-ene-1-carbaldehyde substituted by a prop-1-en-2-yl group at position 4.
Chemical ID: MESH:C033342
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Txn1increases expressionISOTXN (Homo sapiens)6480464CTDperillaldehyde results in increased expression of TXN mRNA; perillaldehyde results in increased expression of TXN proteinPMID:19123792
Txn1multiple interactionsISOTXN (Homo sapiens)6480464CTDKEAP1 protein inhibits the reaction [perillaldehyde results in increased expression of TXN mRNA]; perillaldehyde promotes the reaction [NFE2L2 protein binds to TXN enhancer]PMID:19123792
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