GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Epo | increases expression | EXP | | 6480464 | CTD | Oxygen deficiency results in increased expression of EPO; Oxygen deficiency results in increased expression of EPO mRNA; Oxygen deficiency results in increased expression of EPO protein | PMID:18331222 PMID:19278353 PMID:19497871 PMID:21120517 PMID:23877121 PMID:24557580 PMID:34541741 | Epo | multiple interactions | EXP | | 6480464 | CTD | [Oxygen deficiency co-treated with cobaltous chloride] results in increased expression of EPO mRNA; [Oxygen deficiency co-treated with cobaltous chloride] results in increased expression of EPO protein; Amphotericin B inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]; cyclo(Trp-Asp-Pro-Val-Leu) promotes the reaction [Oxygen deficiency results in increased expression of EPO mRNA]; Diethylstilbestrol inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]; Diethylstilbestrol inhibits the reaction [Oxygen deficiency results in increased expression of EPO protein]; EPO protein inhibits the reaction [Oxygen results in increased expression of ACHE mRNA alternative form] | PMID:16189267 PMID:18331222 PMID:19278353 PMID:19729061 PMID:23877121 PMID:24557580 | Epo | increases expression | ISO | Epo (Mus musculus) | 6480464 | CTD | Oxygen deficiency results in increased expression of EPO mRNA | PMID:10756076 PMID:23437309 PMID:24614111 | Epo | increases expression | ISO | EPO (Homo sapiens) | 6480464 | CTD | Oxygen deficiency results in increased expression of EPO mRNA; Oxygen deficiency results in increased expression of EPO protein | PMID:10866824 PMID:11090055 PMID:11286986 PMID:21566342 PMID:21863063 PMID:23958427 PMID:24614111 PMID:26282490 | Epo | increases secretion | ISO | EPO (Homo sapiens) | 6480464 | CTD | Oxygen deficiency results in increased secretion of EPO protein | PMID:23958427 | Epo | multiple interactions | ISO | Epo (Mus musculus) | 6480464 | CTD | Cycloheximide inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]; Hydrogen Peroxide inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA] | PMID:10756076 | Epo | multiple interactions | ISO | EPO (Homo sapiens) | 6480464 | CTD | 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]; Amphotericin B inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]; Cadmium Chloride inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]; Cadmium Chloride inhibits the reaction [Oxygen deficiency results in increased expression of EPO protein]; Cadmium inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EPO promoter]]; Cadmium inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]; Cisplatin inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]; Cisplatin inhibits the reaction [Oxygen deficiency results in increased expression of EPO protein]; cobaltous chloride inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]; CYP2D6 protein inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]; CYP3A4 protein promotes the reaction [Oxygen deficiency results in increased expression of EPO mRNA]; dihydrotanshinone I inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]; EPAS1 protein affects the reaction [Oxygen deficiency results in increased expression of EPO mRNA]; EPO protein inhibits the reaction [Oxygen deficiency results in increased secretion of EDN1 protein]; Indican inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]; Ketoconazole inhibits the reaction [CYP3A4 protein promotes the reaction [Oxygen deficiency results in increased expression of EPO mRNA]]; Ketoconazole inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]; Mercuric Chloride inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]; Mercuric Chloride inhibits the reaction [Oxygen deficiency results in increased expression of EPO protein]; Nitroprusside inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]; Oxygen deficiency promotes the reaction [[HIF1A protein binds to ARNT protein] which binds to EPO enhancer]; Oxygen deficiency promotes the reaction [HIF1A protein binds to EPO promoter]; zinc chloride inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA] | PMID:10866824 PMID:11090055 PMID:11286986 PMID:16189267 PMID:21566342 PMID:21863063 PMID:23958427 PMID:24557580 PMID:26282490 | | ||||||||||||||||||||||
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