GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ahr | decreases expression | EXP | | 6480464 | CTD | Oxygen deficiency results in decreased expression of AHR protein | PMID:10570039 | Ahr | affects activity | ISO | AHR (Homo sapiens) | 6480464 | CTD | Oxygen deficiency affects the activity of AHR protein | PMID:25596134 | Ahr | affects expression | ISO | AHR (Homo sapiens) | 6480464 | CTD | Oxygen deficiency affects the expression of AHR mRNA | PMID:33811995 | Ahr | affects localization | ISO | AHR (Homo sapiens) | 6480464 | CTD | Oxygen affects the localization of AHR protein; Oxygen deficiency affects the localization of AHR protein | PMID:17599377 PMID:25831079 | Ahr | affects response to substance | ISO | AHR (Homo sapiens) | 6480464 | CTD | AHR affects the susceptibility to Oxygen | PMID:27103661 | Ahr | decreases expression | ISO | Ahr (Mus musculus) | 6480464 | CTD | Oxygen results in decreased expression of AHR mRNA; Oxygen results in decreased expression of AHR protein | PMID:26272953 | Ahr | increases response to substance | ISO | Ahr (Mus musculus) | 6480464 | CTD | AHR gene mutant form results in increased susceptibility to Oxygen | PMID:23337360 | Ahr | multiple interactions | ISO | Ahr (Mus musculus) | 6480464 | CTD | AHR protein affects the reaction [Oxygen results in increased expression of CYP1A1 protein]; AHR protein affects the reaction [Oxygen results in increased expression of MGST1 protein]; AHR protein affects the reaction [Oxygen results in increased expression of NQO1 protein] | PMID:23337360 | Ahr | multiple interactions | ISO | AHR (Homo sapiens) | 6480464 | CTD | [Methylcholanthrene co-treated with Oxygen deficiency] results in increased expression of AHR mRNA; [Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] affects the localization of AHR protein; AHR mutant form inhibits the reaction [Oxygen results in increased expression of CYP1A1 mRNA]; AHR mutant form inhibits the reaction [Oxygen results in increased expression of NQO1 mRNA]; AHR mutant form inhibits the reaction [Oxygen results in increased expression of NQO1 protein]; AHR mutant form inhibits the reaction [Oxygen results in increased expression of RELB protein]; AHR mutant form inhibits the reaction [Oxygen results in increased expression of SOD1 protein]; AHR mutant form promotes the reaction [Oxygen results in increased cleavage of PARP1 protein]; AHR mutant form promotes the reaction [Oxygen results in increased expression of CCL3 protein]; AHR mutant form promotes the reaction [Oxygen results in increased expression of CCL4 protein]; alpha-naphthoflavone inhibits the reaction [[Oxygen deficiency co-treated with Tetrachlorodibenzodioxin] results in decreased stability of AHR protein]; ARNT protein inhibits the reaction [Oxygen deficiency results in decreased activity of AHR protein]; Oxygen affects the reaction [AHR protein results in decreased expression of ACVRL1 mRNA]; Oxygen affects the reaction [AHR protein results in decreased expression of BAD mRNA]; Oxygen affects the reaction [AHR protein results in decreased expression of CALM1 mRNA]; Oxygen affects the reaction [AHR protein results in decreased expression of CCL2 mRNA]; Oxygen affects the reaction [AHR protein results in decreased expression of CCND2 mRNA]; Oxygen affects the reaction [AHR protein results in decreased expression of CDKN1A mRNA]; Oxygen affects the reaction [AHR protein results in decreased expression of KLF11 mRNA]; Oxygen affects the reaction [AHR protein results in decreased expression of MXD4 mRNA]; Oxygen affects the reaction [AHR protein results in decreased expression of SMAD3 mRNA]; Oxygen affects the reaction [AHR protein results in decreased expression of TNF mRNA]; Oxygen affects the reaction [AHR protein results in increased expression of ADRB2 mRNA]; Oxygen affects the reaction [AHR protein results in increased expression of ANXA1 mRNA]; Oxygen affects the reaction [AHR protein results in increased expression of CCL3 mRNA]; Oxygen affects the reaction [AHR protein results in increased expression of CCL5 mRNA]; Oxygen affects the reaction [AHR protein results in increased expression of CXCL10 mRNA]; Oxygen affects the reaction [AHR protein results in increased expression of FST mRNA]; Oxygen affects the reaction [AHR protein results in increased expression of KLF4 mRNA]; Oxygen affects the reaction [AHR protein results in increased expression of KPNA2 mRNA]; Oxygen affects the reaction [AHR protein results in increased expression of PRIM1 mRNA]; Oxygen affects the reaction [AHR protein results in increased expression of ZBTB16 mRNA]; Oxygen deficiency affects the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased activity of AHR protein]; Oxygen deficiency inhibits the reaction [AHR protein binds to CYP1A1 promoter]; Oxygen deficiency inhibits the reaction [AHR protein binds to CYP1B1 promoter]; Oxygen deficiency inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of AHR mRNA]; Oxygen deficiency promotes the reaction [Acetaminophen results in increased expression of AHR mRNA] | PMID:18072750 PMID:24355420 PMID:25831079 PMID:27103661 PMID:33811995 | | ||||||||||||||||||||||
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