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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2069
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Agt
Name: angiotensinogen
Acc ID: CHEBI:15379
Term: dioxygen
Definition: An elemental molecule that has formula O2.
Chemical ID: MESH:D010100
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Agtdecreases expressionEXP 6480464CTDOxygen deficiency results in decreased expression of AGT proteinPMID:19118600
Agtincreases abundanceEXP 6480464CTDAGT protein results in increased abundance of OxygenPMID:14597645
Agtmultiple interactionsEXP 6480464CTD[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of and results in increased secretion of AGT protein modified form; acetovanillone inhibits the reaction [AGT protein results in increased abundance of Oxygen]; bisphenol A inhibits the reaction [Estradiol inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of and results in increased secretion of AGT protein modified form]]; Estradiol inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of and results in increased secretion of AGT protein modified form]; Oxygen deficiency promotes the reaction [AGT protein results in increased expression of NOS3 protein]; Oxygen deficiency promotes the reaction [AGT protein results in increased expression of VEGFA protein]; tempol inhibits the reaction [AGT protein results in increased abundance of Oxygen]; Valsartan inhibits the reaction [AGT protein results in increased abundance of Oxygen]; Valsartan inhibits the reaction [Oxygen deficiency promotes the reaction [AGT protein results in increased expression of NOS3 protein]]; Valsartan inhibits the reaction [Oxygen deficiency promotes the reaction [AGT protein results in increased expression of VEGFA protein]]PMID:11897773 PMID:14597645 PMID:32319667
Agtmultiple interactionsISOAgt (Mus musculus)6480464CTDOxygen deficiency results in increased expression of and results in increased secretion of AGT proteinPMID:25511041
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