GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Kcna5 | decreases expression | EXP | | 6480464 | CTD | Oxygen results in decreased expression of KCNA5 protein | PMID:25447406 | Kcna5 | decreases activity | ISO | Kcna5 (Rattus norvegicus) | 6480464 | CTD | Oxygen deficiency results in decreased activity of KCNA5 protein | PMID:18984061 | Kcna5 | decreases expression | ISO | Kcna5 (Rattus norvegicus) | 6480464 | CTD | Oxygen deficiency results in decreased expression of KCNA5 mRNA; Oxygen deficiency results in decreased expression of KCNA5 protein | PMID:18984061 PMID:31930969 | Kcna5 | multiple interactions | ISO | Kcna5 (Rattus norvegicus) | 6480464 | CTD | (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide inhibits the reaction [Apigenin inhibits the reaction [Oxygen deficiency results in decreased expression of KCNA5 protein]]; [[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid] which results in decreased expression of KCNA5 mRNA; [[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid] which results in decreased expression of KCNA5 protein; ALOX15 protein promotes the reaction [Oxygen deficiency results in decreased activity of KCNA5 protein]; Apigenin inhibits the reaction [Oxygen deficiency results in decreased expression of KCNA5 protein]; cinnamyl-3,4-dihydroxycyanocinnamate inhibits the reaction [[[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid] which results in decreased expression of KCNA5 mRNA]; HIF1A protein inhibits the reaction [Apigenin inhibits the reaction [Oxygen deficiency results in decreased expression of KCNA5 protein]]; Masoprocol inhibits the reaction [[[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid] which results in decreased expression of KCNA5 mRNA] | PMID:18984061 PMID:31930969 | | ||||||||||||||||||||||
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