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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3732
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod2
Name: superoxide dismutase 2
Acc ID: CHEBI:15368
Term: acrolein
Definition: An enal that is prop-2-ene with an oxo group at position 1.
Chemical ID: MESH:D000171
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod2decreases activityEXP 6480464CTDAcrolein results in decreased activity of SOD2 proteinPMID:34238125
Sod2increases expressionEXP 6480464CTDAcrolein results in increased expression of SOD2 mRNAPMID:35150775
Sod2multiple interactionsEXP 6480464CTDLinoleic Acids, Conjugated inhibits the reaction [Acrolein results in decreased activity of SOD2 protein]PMID:34238125
Sod2increases expressionISOSod2 (Mus musculus)6480464CTDAcrolein results in increased expression of SOD2 proteinPMID:28482051
Sod2increases expressionISOSOD2 (Homo sapiens)6480464CTDAcrolein results in increased expression of SOD2 proteinPMID:24008411
Sod2multiple interactionsISOSOD2 (Homo sapiens)6480464CTD[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of SOD2 mRNA; [Acrolein co-treated with methacrylaldehyde co-treated with Ozone] results in decreased expression of SOD2 mRNA; [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of SOD2 mRNA; coenzyme Q10 inhibits the reaction [Acrolein results in increased expression of SOD2 protein]; Resveratrol inhibits the reaction [Acrolein results in increased expression of SOD2 protein]PMID:24008411 PMID:32699268 PMID:32845096
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