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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732280 Species: Mus musculus RGD Object: Gene Symbol: Ccr1 Name: chemokine (C-C motif) receptor 1

Acc ID: CHEBI:15367 Term: all-trans-retinoic acid Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry. CasRN: 302-79-4 Chemical ID: MESH:D014212

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:1349625	6480464	CTD	Tretinoin results in increased expression of CCR1 mRNA	PMID:19828696
increases expression	ISO	RGD:1349625	6480464	CTD	Tretinoin results in increased expression of CCR1 mRNA	PMID:15498508 PMID:19828696
increases expression	ISO	RGD:1349625	6480464	CTD	Tretinoin results in increased expression of CCR1 mRNA	PMID:15498508 PMID:15894607 PMID:19828696
multiple interactions	ISO	RGD:1349625	6480464	CTD	[Tretinoin co-treated with arsenic trioxide] results in increased expression of CCR1 mRNA	PMID:15894607