Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tgm2
Name: transglutaminase 2
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgm2increases expressionEXP 6480464CTDTretinoin results in increased expression of TGM2 mRNAPMID:20488242
Tgm2increases activityISOTGM2 (Homo sapiens)6480464CTDTretinoin results in increased activity of TGM2 proteinPMID:2884032 PMID:9516142
Tgm2increases expressionISOTGM2 (Homo sapiens)6480464CTDTretinoin results in increased expression of TGM2 mRNA; Tretinoin results in increased expression of TGM2 proteinPMID:10910994 PMID:11133770 PMID:12075115 PMID:16054129 PMID:16140955 PMID:16158052 PMID:16480812 PMID:16982809 PMID:17034753 PMID:23724009 PMID:30076181 PMID:33167477 PMID:9450572 PMID:9516142
Tgm2increases expressionISOTgm2 (Mus musculus)6480464CTDTretinoin results in increased expression of TGM2 mRNAPMID:16505366 PMID:16604517
Tgm2multiple interactionsISOTGM2 (Homo sapiens)6480464CTD2-bromopalmitate promotes the reaction [Tretinoin results in increased expression of TGM2 mRNA]; 4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid inhibits the reaction [Tretinoin results in increased expression of TGM2 mRNA]; [Hemin co-treated with Tretinoin] affects the localization of TGM2 protein; AGN 193109 inhibits the reaction [Tretinoin results in increased expression of TGM2 protein]; Arsenic Trioxide inhibits the reaction [Tretinoin results in increased expression of TGM2 protein]; Butyrates inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Tretinoin results in increased expression of TGM2 mRNA]]; CD 2425 promotes the reaction [Tretinoin results in increased expression of TGM2 mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [Tretinoin results in increased expression of TGM2 mRNA]; Thiophenes analog promotes the reaction [Tretinoin results in increased expression of TGM2 mRNA]; Tretinoin results in increased expression of and results in increased activity of TGM2 proteinPMID:10910994 PMID:11133770 PMID:12075115 PMID:15556610 PMID:16140955 PMID:16158052 PMID:16158929 PMID:30076181 PMID:9450572 PMID:9516142
Go Back to source page   Continue to Ontology report