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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619567 Species: Homo sapiens RGD Object: Gene Symbol: BGLAP Name: bone gamma-carboxyglutamate (gla) protein

Acc ID: CHEBI:15367 Term: all-trans-retinoic acid Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry. CasRN: 302-79-4 Chemical ID: MESH:D014212

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO		6480464	CTD	[Tretinoin co-treated with Cholecalciferol] results in increased expression of BGLAP	PMID:17170073
decreases expression	ISO		6480464	CTD	Tretinoin results in decreased expression of BGLAP mRNA	PMID:16350840 PMID:16392701
increases expression	ISO		6480464	CTD	Tretinoin results in increased expression of BGLAP mRNA	PMID:16889531
decreases expression	ISO	RGD:1621635	6480464	CTD	Tretinoin results in decreased expression of BGLAP mRNA	PMID:16392701 PMID:16350840
multiple interactions	ISO	RGD:1621635	6480464	CTD	[Tretinoin co-treated with Cholecalciferol] results in increased expression of BGLAP	PMID:17170073
increases expression	ISO	RGD:1621635	6480464	CTD	Tretinoin results in increased expression of BGLAP mRNA	PMID:16889531
decreases expression	ISO		6480464	CTD	Tretinoin results in decreased expression of BGLAP mRNA	PMID:16392701 PMID:16350840
decreases expression	ISO	RGD:1621635	6480464	CTD	Tretinoin results in decreased expression of BGLAP mRNA	PMID:16350840 PMID:16392701
multiple interactions	ISO	RGD:1621634	6480464	CTD	[Tretinoin co-treated with Cholecalciferol] results in increased expression of BGLAP	PMID:17170073
decreases expression	ISO	RGD:1621634	6480464	CTD	Tretinoin results in decreased expression of BGLAP mRNA	PMID:16350840 PMID:16392701
increases expression	ISO	RGD:1621634	6480464	CTD	Tretinoin results in increased expression of BGLAP mRNA	PMID:16889531