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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3651
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cxcl12
Name: C-X-C motif chemokine ligand 12
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcl12decreases expressionEXP 6480464CTDTretinoin results in decreased expression of CXCL12 mRNAPMID:20488242
Cxcl12affects expressionISOCXCL12 (Homo sapiens)6480464CTDTretinoin affects the expression of CXCL12 mRNAPMID:31600526
Cxcl12increases expressionISOCXCL12 (Homo sapiens)6480464CTDTretinoin results in increased expression of CXCL12 mRNA; Tretinoin results in increased expression of CXCL12 proteinPMID:17656649
Cxcl12multiple interactionsISOCxcl12 (Mus musculus)6480464CTD[bisphenol A co-treated with Tretinoin] results in decreased expression of CXCL12 mRNAPMID:30951980
Cxcl12multiple interactionsISOCXCL12 (Homo sapiens)6480464CTD[Tretinoin co-treated with CXCL12 protein] results in increased expression of CDKN1A protein; [Tretinoin co-treated with CXCL12 protein] results in increased expression of CEBPB protein; [Tretinoin co-treated with CXCL12 protein] results in increased expression of PTK2B protein; Tretinoin promotes the reaction [CEBPB protein binds to CXCL12 promoter]PMID:17656649
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