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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3632
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Scn2a
Name: sodium voltage-gated channel alpha subunit 2
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Scn2aincreases expressionISOSCN2A (Homo sapiens)6480464CTDTretinoin results in increased expression of SCN2A mRNAPMID:26655721
Scn2amultiple interactionsISOSCN2A (Homo sapiens)6480464CTD[Tretinoin co-treated with Phenylbutyrates co-treated with 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene] results in increased expression of SCN2A mRNA; [Tretinoin co-treated with Phenylbutyrates co-treated with 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene] results in increased expression of SCN2A protein; Tretinoin promotes the reaction [ZMYND8 protein binds to SCN2A gene]; Tretinoin promotes the reaction [ZMYND8 protein binds to SCN2A promoter]; ZMYND8 protein affects the reaction [Tretinoin results in increased expression of SCN2A mRNA]PMID:23284745 PMID:26655721
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