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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3044 Species: Rattus norvegicus RGD Object: Gene Symbol: Map2 Name: microtubule-associated protein 2

Acc ID: CHEBI:15367 Term: all-trans-retinoic acid Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry. CasRN: 302-79-4 Chemical ID: MESH:D014212

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:733668	6480464	CTD	[NTF3 protein co-treated with Tretinoin] results in increased expression of MAP2 protein	PMID:16996685
increases expression	ISO	RGD:733668	6480464	CTD	Tretinoin results in increased expression of MAP2 protein	PMID:15464216
increases expression	ISO	RGD:733669	6480464	CTD	Tretinoin results in increased expression of MTAP2 mRNA Tretinoin results in increased expression of MAP2 mRNA	PMID:16424397
increases expression	EXP		6480464	CTD	Tretinoin results in increased expression of MTAP2 protein	PMID:17130476 PMID:16944780
increases expression	EXP		6480464	CTD	Tretinoin results in increased expression of MTAP2 protein Tretinoin results in increased expression of MAP2 protein	PMID:16944780 PMID:17130476
decreases expression	ISO	RGD:733668	6480464	CTD	Tretinoin results in decreased expression of MAP2 mRNA	PMID:21934132