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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2544 Species: Rattus norvegicus RGD Object: Gene Symbol: Egr1 Name: early growth response 1

Acc ID: CHEBI:15367 Term: all-trans-retinoic acid Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry. CasRN: 302-79-4 Chemical ID: MESH:D014212

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:737111	6480464	CTD	Tretinoin results in increased expression of EGR1 mRNA	PMID:16012519
multiple interactions	ISO	RGD:10512	6480464	CTD	Tretinoin promotes the reaction [arsenic trioxide results in increased expression of EGR1 mRNA]	PMID:15688020