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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2307
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cd44
Name: CD44 molecule
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cd44decreases expressionISOCd44 (Mus musculus)6480464CTDTretinoin results in decreased expression of CD44 mRNAPMID:22498432
Cd44decreases expressionISOCD44 (Homo sapiens)6480464CTDTretinoin results in decreased expression of CD44 mRNA; Tretinoin results in decreased expression of CD44 mRNA alternative formPMID:15498508 PMID:17349212 PMID:22391160 PMID:23724009 PMID:23830798
Cd44increases expressionISOCd44 (Mus musculus)6480464CTDTretinoin results in increased expression of CD44 proteinPMID:16724877
Cd44increases expressionISOCD44 (Homo sapiens)6480464CTDTretinoin results in increased expression of CD44 mRNAPMID:15894607 PMID:21934132
Cd44multiple interactionsISOCd44 (Mus musculus)6480464CTD[bisphenol A co-treated with Tretinoin] results in decreased expression of CD44 mRNA; [bisphenol F co-treated with Tretinoin] results in decreased expression of CD44 mRNA; [bisphenol S co-treated with Tretinoin] results in decreased expression of CD44 mRNAPMID:30951980
Cd44multiple interactionsISOCD44 (Homo sapiens)6480464CTD[Tretinoin co-treated with arsenic trioxide] results in increased expression of CD44 mRNAPMID:15894607
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