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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1553182 Species: Mus musculus RGD Object: Gene Symbol: Casp7 Name: caspase 7

Acc ID: CHEBI:15367 Term: all-trans-retinoic acid Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry. CasRN: 302-79-4 Chemical ID: MESH:D014212

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1298347	6480464	CTD	CRABP2 protein promotes the reaction [Tretinoin results in increased cleavage of and results in increased activity of CASP7 protein] Cycloheximide inhibits the reaction [Tretinoin results in increased expression of CASP7 mRNA]	PMID:16166294
multiple interactions	ISO	RGD:1298347	6480464	CTD	[Tretinoin co-treated with zoledronic acid] results in increased activity of CASP7 protein	PMID:20349282
increases expression	ISO	RGD:1298347	6480464	CTD	Tretinoin results in increased expression of CASP7 mRNA	PMID:16166294
multiple interactions	EXP		6480464	CTD	Tretinoin promotes the reaction [arsenic trioxide results in increased cleavage of CASP7 protein]	PMID:15688020
increases expression	ISO	RGD:1298347	6480464	CTD	Tretinoin results in increased expression of CASP7 mRNA	PMID:15894607 PMID:16166294