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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1350990 Species: Homo sapiens RGD Object: Gene Symbol: GALM Name: galactose mutarotase (aldose 1-epimerase)

Acc ID: CHEBI:15367 Term: all-trans-retinoic acid Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry. CasRN: 302-79-4 Chemical ID: MESH:D014212

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	EXP		6480464	CTD	Tretinoin results in increased expression of GALM mRNA Tretinoin results in increased expression of GALM protein	PMID:18052213
multiple interactions	EXP		6480464	CTD	Dactinomycin inhibits the reaction [Tretinoin results in increased expression of GALM mRNA]	PMID:18052213
increases expression	EXP		6480464	CTD	Tretinoin results in increased expression of GALM mRNA	PMID:15894607 PMID:18052213
multiple interactions	EXP		6480464	CTD	[Tretinoin co-treated with arsenic trioxide] results in increased expression of GALM mRNA	PMID:15894607