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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1313526 Species: Mus musculus RGD Object: Gene Symbol: Mki67 Name: antigen identified by monoclonal antibody Ki 67

Acc ID: CHEBI:15367 Term: all-trans-retinoic acid Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry. CasRN: 302-79-4 Chemical ID: MESH:D014212

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:1313525	6480464	CTD	Tretinoin results in decreased expression of MKI67 protein	PMID:16461808
decreases expression	ISO	RGD:1313525	6480464	CTD	Tretinoin results in decreased expression of MKI67 mRNA	PMID:16249480
multiple interactions	ISO	RGD:1305476	6480464	CTD	Tretinoin inhibits the reaction [sodium arsenite results in decreased expression of MKI67 protein]	PMID:21964460