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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308443 Species: Rattus norvegicus RGD Object: Gene Symbol: Nkx2-2 Name: NK2 homeobox 2

Acc ID: CHEBI:15367 Term: all-trans-retinoic acid Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry. CasRN: 302-79-4 Chemical ID: MESH:D014212

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1318213	6480464	CTD	[Tretinoin co-treated with EGF protein] results in increased expression of NKX2-2 mRNA	PMID:17196394
multiple interactions	ISO	RGD:1318214	6480464	CTD	[Tretinoin co-treated with SHH protein] results in increased expression of NKX2-2 protein	PMID:15996115