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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70967
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp6
Name: caspase 6
Acc ID: CHEBI:15365
Term: acetylsalicylic acid
Definition: A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Chemical ID: MESH:D001241
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp6multiple interactionsISOCASP6 (Homo sapiens)6480464CTDAspirin inhibits the reaction [Deoxycholic Acid results in increased activity of CASP6 protein]; Aspirin results in increased cleavage of and results in increased activity of CASP6 proteinPMID:15481331 PMID:17644113
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