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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69051
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tgfb1
Name: transforming growth factor, beta 1
Acc ID: CHEBI:15365
Term: acetylsalicylic acid
Definition: A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Chemical ID: MESH:D001241
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgfb1decreases expressionEXP 6480464CTDAspirin results in decreased expression of TGFB1 mRNAPMID:12566377
Tgfb1multiple interactionsEXP 6480464CTDAspirin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; Aspirin inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]PMID:14586741 PMID:21360558
Tgfb1decreases expressionISOTGFB1 (Homo sapiens)6480464CTDAspirin results in decreased expression of TGFB1 mRNAPMID:15928584
Tgfb1increases response to substanceISOTGFB1 (Homo sapiens)6480464CTDTGFB1 promoter SNP results in increased susceptibility to AspirinPMID:19138248
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