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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3772
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stat3
Name: signal transducer and activator of transcription 3
Acc ID: CHEBI:15365
Term: acetylsalicylic acid
Definition: A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Chemical ID: MESH:D001241
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat3decreases expressionISOSTAT3 (Homo sapiens)6480464CTDAspirin results in decreased expression of STAT3 mRNA; Aspirin results in decreased expression of STAT3 protein modified formPMID:11906190 PMID:19595669
Stat3decreases phosphorylationISOStat3 (Mus musculus)6480464CTDAspirin results in decreased phosphorylation of STAT3 proteinPMID:20886344
Stat3multiple interactionsISOSTAT3 (Homo sapiens)6480464CTDIL6 protein inhibits the reaction [Aspirin results in decreased expression of STAT3 protein modified form]PMID:19595669
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