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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345363 Species: Homo sapiens RGD Object: Gene Symbol: ITGB3 Name: integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)

Acc ID: CHEBI:15365 Term: acetylsalicylic acid Definition: Benzoic acid carrying an acetoxy group at the 2-position. A non-steroidal anti-inflammatory drug with moA cyclooxygenase inhibitor activity. CasRN: 50-78-2 Chemical ID: MESH:D001241

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	Aspirin results in decreased expression of [ITGA2B protein binds to ITGB3 protein]	PMID:15381054
affects response to substance	EXP		6480464	CTD	ITGB3 gene polymorphism affects the susceptibility to Aspirin	PMID:17184645
multiple interactions	EXP		6480464	CTD	ITGB3 polymorphism affects the reaction [Aspirin affects the cleavage of F2 protein]	PMID:16675000
decreases response to substance	EXP		6480464	CTD	ITGB3 gene polymorphism results in decreased susceptibility to Aspirin	PMID:13678940
decreases response to substance	EXP		6480464	CTD	ITGB3 polymorphism results in decreased susceptibility to Aspirin	PMID:16153930
decreases response to substance	EXP		6480464	CTD	ITGB3 results in decreased susceptibility to Aspirin	PMID:15840736
multiple interactions	EXP		6480464	CTD	Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of ITGB3 protein] Glucose inhibits the reaction [Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of ITGB3 protein]]	PMID:18413191
increases expression	ISO	RGD:737483	6480464	CTD	Aspirin results in increased expression of ITGB3 mRNA Aspirin results in increased expression of ITGB3 protein	PMID:21035850