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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69051
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tgfb1
Name: transforming growth factor, beta 1
Acc ID: CHEBI:15354
Term: choline
Definition: A choline that is the parent compound of the cholines class, consisting of ethanolamine having three methyl substituents attached to the amino function.
Chemical ID: MESH:D002794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgfb1multiple interactionsISOTgfb1 (Mus musculus)6480464CTD[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TGFB1 mRNA; [Choline deficiency co-treated with Methionine deficiency] results in increased expression of TGFB1 protein; [Dietary Fats co-treated with Choline deficiency co-treated with Methionine deficiency] results in increased expression of TGFB1 mRNA; [Dietary Fats co-treated with Choline deficiency co-treated with Methionine deficiency] results in increased expression of TGFB1 protein; [Methionine deficiency co-treated with Choline deficiency co-treated with Dietary Fats] results in increased expression of TGFB1 mRNA; [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TGFB1 gene; [Methionine deficiency co-treated with Choline deficiency] results in increased expression of TGFB1 mRNA; [Methionine deficiency co-treated with Choline deficiency] results in increased expression of TGFB1 protein; alisol A 24-acetate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TGFB1 mRNA]; alisol A 24-acetate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TGFB1 protein]; alisol A 24-acetate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TGFB1 mRNA]; Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TGFB1 mRNA]; caryophyllene inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TGFB1 mRNA]; Chenodeoxycholic Acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TGFB1 mRNA]; Chenodeoxycholic Acid inhibits the reaction [alisol A 24-acetate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TGFB1 mRNA]]; Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TGFB1 mRNA]; fuzheng huayu inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TGFB1 mRNA]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TGFB1 mRNA]]; olaparib inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TGFB1 mRNA]; Rosiglitazone inhibits the reaction [[Dietary Fats co-treated with Choline deficiency co-treated with Methionine deficiency] results in increased expression of TGFB1 mRNA]; Rosiglitazone inhibits the reaction [[Dietary Fats co-treated with Choline deficiency co-treated with Methionine deficiency] results in increased expression of TGFB1 protein]; Smoke affects the reaction [[Methionine deficiency co-treated with Choline deficiency co-treated with Dietary Fats] results in increased expression of TGFB1 mRNA]; tianhuang inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TGFB1 mRNA]PMID:18513333 PMID:18991162 PMID:19593819 PMID:20938992 PMID:27773935 PMID:27984176 PMID:29097836 PMID:29883724 PMID:30745416 PMID:31678261 PMID:38042390
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