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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:15354
Term: choline
Definition: A choline that is the parent compound of the cholines class, consisting of ethanolamine having three methyl substituents attached to the amino function.
Chemical ID: MESH:D002794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2multiple interactionsISONfe2l2 (Mus musculus)6480464CTD[Methionine deficiency co-treated with Choline deficiency] affects the localization of NFE2L2 protein; NFE2L2 affects the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of CD36 mRNA]; NFE2L2 affects the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of FGF21 mRNA]; NFE2L2 affects the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of GCLC mRNA]; NFE2L2 affects the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of KEAP1 mRNA]; NFE2L2 affects the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of NQO1 mRNA]; NFE2L2 affects the susceptibility to [Choline deficiency co-treated with Methionine deficiency]PMID:20350562
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