GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp1a2 | multiple interactions | EXP | | 6480464 | CTD | Choline deficiency inhibits the reaction [Acetaminophen results in increased expression of CYP1A2 protein]; Choline deficiency promotes the reaction [Phenobarbital results in increased expression of CYP1A2 protein] | PMID:18798224 | Cyp1a2 | multiple interactions | ISO | Cyp1a2 (Mus musculus) | 6480464 | CTD | [3,4,5,3',4'-pentachlorobiphenyl co-treated with Methionine deficiency co-treated with Choline deficiency] results in increased expression of CYP1A2 mRNA; [Choline deficiency co-treated with Folic Acid deficiency co-treated with Methionine deficiency] results in decreased expression of CYP1A2 mRNA; [LEP gene mutant form results in increased susceptibility to [Methionine co-treated with Choline]] which results in decreased expression of CYP1A2 mRNA; [LEP gene mutant form results in increased susceptibility to [Methionine co-treated with Choline]] which results in decreased expression of CYP1A2 protein; [Methionine deficiency co-treated with Choline deficiency co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of CYP1A2 mRNA | PMID:27712037 PMID:28163111 PMID:28973532 PMID:29127188 | |
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