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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345007 Species: Homo sapiens RGD Object: Gene Symbol: CYP2E1 Name: cytochrome P450, family 2, subfamily E, polypeptide 1

Acc ID: CHEBI:15354 Term: choline Definition: A choline that is the parent compound of the cholines class, consisting of ethanolamine having three methyl substituents attached to the amino function. CasRN: 62-49-7 Chemical ID: MESH:D002794

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:2475	6480464	CTD	Choline deficiency promotes the reaction [Acetaminophen results in increased expression of CYP2E1 protein] Choline deficiency promotes the reaction [Phenobarbital results in increased expression of CYP2E1 protein]	PMID:18798224
multiple interactions	ISO	RGD:10451	6480464	CTD	[Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate] inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]	PMID:20118189
multiple interactions	ISO	RGD:10451	6480464	CTD	[Methionine deficiency co-treated with Choline deficiency] results in increased activity of CYP2E1 protein RXRA gene mutant form inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased activity of CYP2E1 protein]	PMID:18952117