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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:15347
Term: acetone
Definition: A methyl ketone that consists of propane bearing an oxo group at C2.
Chemical ID: MESH:D000096
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2increases expression EXP 401900656RGDacetone increased expression of Cyp1a2 protein in thoracic aorta of rats 
Cyp1a2multiple interactionsEXP 6480464CTDAcetone promotes the reaction [Toluene results in increased expression of CYP1A2 protein]PMID:8996725
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