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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69219
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aldh2
Name: aldehyde dehydrogenase 2 family member
Acc ID: CHEBI:15343
Term: acetaldehyde
Definition: The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.
Chemical ID: MESH:D000079
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aldh2decreases expressionEXP 6480464CTDAcetaldehyde results in decreased expression of ALDH2 proteinPMID:28017615
Aldh2increases metabolic processingEXP 6480464CTDALDH2 protein results in increased metabolism of AcetaldehydePMID:11535626 PMID:15629893 PMID:16131845 PMID:17010440
Aldh2multiple interactionsEXP 6480464CTD[N-Methyl-3,4-methylenedioxyamphetamine results in decreased activity of ALDH2 protein] which results in increased abundance of Acetaldehyde; N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Acetaldehyde results in decreased expression of ALDH2 protein]PMID:19446252 PMID:28017615
Aldh2affects metabolic processingISOALDH2 (Homo sapiens)6480464CTDALDH2 protein polymorphism affects the metabolism of AcetaldehydePMID:11744614
Aldh2affects oxidationISOALDH2 (Homo sapiens)6480464CTDALDH2 gene polymorphism affects the oxidation of AcetaldehydePMID:19393179
Aldh2affects response to substanceISOAldh2 (Mus musculus)6480464CTDALDH2 protein affects the susceptibility to AcetaldehydePMID:18303182
Aldh2affects response to substanceISOALDH2 (Homo sapiens)6480464CTDALDH2 gene polymorphism affects the susceptibility to AcetaldehydePMID:15840430
Aldh2decreases metabolic processingISOAldh2 (Mus musculus)6480464CTDALDH2 protein mutant form results in decreased metabolism of AcetaldehydePMID:16340452
Aldh2decreases metabolic processingISOALDH2 (Homo sapiens)6480464CTDALDH2 gene polymorphism results in decreased metabolism of Acetaldehyde; ALDH2 protein polymorphism results in decreased metabolism of AcetaldehydePMID:15380331 PMID:8512495
Aldh2decreases response to substanceISOALDH2 (Homo sapiens)6480464CTDALDH2 protein results in decreased susceptibility to AcetaldehydePMID:14722101
Aldh2increases chemical synthesisISOALDH2 (Homo sapiens)6480464CTDALDH2 protein results in increased chemical synthesis of AcetaldehydePMID:10940605
Aldh2increases metabolic processingISOAldh2 (Mus musculus)6480464CTDALDH2 protein results in increased metabolism of AcetaldehydePMID:16340452
Aldh2increases metabolic processingISOALDH2 (Homo sapiens)6480464CTDALDH2 protein results in increased metabolism of AcetaldehydePMID:10780266 PMID:10826103 PMID:15380331 PMID:8850269 PMID:9273829
Aldh2increases oxidationISOALDH2 (Homo sapiens)6480464CTDALDH2 protein results in increased oxidation of AcetaldehydePMID:18940187 PMID:19393179
Aldh2increases response to substanceISOALDH2 (Homo sapiens)6480464CTDALDH2 protein results in increased susceptibility to AcetaldehydePMID:15840430
Aldh2multiple interactionsISOAldh2 (Mus musculus)6480464CTD[CGA protein results in increased abundance of Acetaldehyde] which results in increased expression of ALDH2 mRNAPMID:22285649
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